Evaluation of a single-dose, extended-release epidural morphine formulation for
pain control after lumbar spine surgery.
Author(s): Vineyard JC(1), Toohey JS, Neidre A, Fogel G, Joyner R.
Affiliation(s): Author information:
(1)W.B. Carrell Memorial Clinic, Dallas, Texas.
Publication date & source: 2014, J Surg Orthop Adv. , 23(1):9-12
DepoDur, an extended-release epidural morphine, has been used effectively for
postoperative pain control following many orthopaedic and general surgery
procedures and has provided prolonged analgesia when compared with Duramorph. The
goal of this article was to compare the safety and analgesic efficacy of DepoDur
versus Duramorph after lumbar spine surgery. A prospective, randomized,
double-blind clinical study was completed at a single extended-stay ambulatory
surgery center. All patients over 18 undergoing posterior lumbar spine fusions
were considered for the study. Sixty patients were randomly assigned to a control
or treatment group. The control group received DepoDur before surgery, while the
treatment group received Duramorph. Although results show no significant
differences between the two groups in postoperative visual analog pain scale
scores, use of pain medication, and adverse events, subjects receiving DepoDur
were less likely to receive Naloxone and oxygen supplementation, experience
nausea or fever, and were more likely to experience hypotension. DepoDur proved
to be safe and effective, offering similar prolonged analgesic activity when
compared with Duramorph.
|