Esomeprazole versus pantoprazole for healing erosive oesophagitis.

Author(s): Vcev A, Begic I, Ostojic R, Jurcic D, Bozic D, Soldo I, Gmajnic R, Kondza G, Khaznadar E, Micunovic N

Affiliation(s): Department of Internal Medicine, School of Medicine, University J.J. Strossmayer, Osijek, Croatia. vcev.aleksandar@kbo.hr

Publication date & source: 2006-09, Coll Antropol., 30(3):519-22.

Publication type: Multicenter Study; Randomized Controlled Trial

The aim of this study was to compare the efficacy of esomeprazole and pantoprazole with regard to healing and relief from gastroesophageal reflux disease-related symptoms. I this multicentre, randomized, single-blind study 180 patients (ITT population) diagnosed with endoscopically proven GERD grade A,B,C received esomeprazole (40 mg once daily (o.d.), n = 90) orpantoprazole (40 mg o.d., n = 90). Healing and relief from GERD-related symptoms were assessed at first and final visit (after 4 or 8 weeks of treatment). Esomeprazole 40 mg provided significantly greater healing than pantoprazole 40 mg after 4 weeks of treatment in patients with EE (77.8% vs. 72.2%). Esomeprazole-treated patients were healed after up to 8 weeks of treatment similar those treated with pantoprazole (92.2% vs. 91.1%). The proportion of heartburn-free days was similar in patients treated with esomeprazole and to those treated with pantoprazole.