Long-term immunogenicity and immune memory after two doses of the adult formulation of a combined hepatitis A and B vaccine in children 1 to 11 years of age.
Author(s): van Damme P, Kafeja F, Van Der Wielen M, Leyssen M, Jacquet JM
Affiliation(s): Centre for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute (WHO Collaborating Centre), University of Antwerp, Antwerpen, Belgium. pierre.vandamme@ua.ac.be
Publication date & source: 2011-08, Pediatr Infect Dis J., 30(8):703-5.
Publication type: Research Support, Non-U.S. Gov't
Long-term persistence of antibodies against hepatitis A and B (anti-HAV and anti-HBs) were evaluated in 1- to 11-year-old children following 2 doses (0, 6 months) of hepatitis A and B vaccine. Ten years postvaccination, all subjects were anti-HAV seropositive (>/=15 mIU/mL), 81.7% had anti-HBs antibody concentrations >/=10 mIU/mL. All subjects with anti-HBs concentrations <10 mIU/mL, mounted a vigorous anamnestic response to an HBV vaccine challenge dose indicating the presence of immunologic memory against hepatitis B.
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