Porphyria cutanea tarda: pregnancy versus estrogen effect.
Author(s): Urbanek RW, Cohen DJ
Affiliation(s): Department of Medicine, Staten Island University Hospital, NY 10305.
Publication date & source: 1994-08, J Am Acad Dermatol., 31(2 Pt 2):390-2.
Publication type: Case Reports
We describe the worsening of porphyria cutanea tarda in a young woman while she was taking oral contraceptives. However, she did not have an exacerbation during two pregnancies. We conclude that estrogens produced during pregnancy do not exert the same effect as orally administered medications that contain estrogen. The pronounced effect of oral ethinyl estradiol on the liver may be attributed to its first-pass effect on that organ.
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