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Imipramine reverses the depressive symptoms in sepsis survivor rats.

Author(s): Tuon L, Comim CM, Antunes MM, Constantino LS, Machado RA, Izquierdo I, Quevedo J, Dal-Pizzol F

Affiliation(s): Laboratorio de Neurociencias, Programa de Pos-Graduacao Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806-000 Criciuma, Brazil.

Publication date & source: 2007-12, Intensive Care Med., 33(12):2165-7. Epub 2007 Aug 1.

Publication type: Research Support, Non-U.S. Gov't

OBJECTIVE: To evaluate the antidepressant effect of imipramine on depressive symptoms observed in sepsis survivors rats. DESIGN AND SETTING: Prospective, controlled experiment in an animal basic science laboratory. SUBJECTS: Male Wistar rats weighing 300-350 g. INTERVENTIONS: The rats underwent cecal ligation and perforation (CLP; sepsis group) with "basic support" (saline at 50 ml/kg immediately and 12 h after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 h after CLP) or sham-operated (control group). After 10 days of recovery rats received intraperitoneal injections of imipramine 10 mg/kg or saline and were subjected to the forced swimming test. MEASUREMENTS AND RESULTS: The observed increase in the immobility time in the forced swimming test in animals subjected to CLP, as a parameter of depressive behavior, was reversed by imipramine. CONCLUSIONS: The depressive symptoms evaluated by forced swimming test had been reversed after imipramine administration. Our data provide evidence that CLP-induced depressive symptoms are sensitive to antidepressants.

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