Topical nadifloxacin 1% cream vs. topical erythromycin 4% gel in the treatment of
mild to moderate acne.
Author(s): Tunca M, Akar A, Ozmen I, Erbil H.
Affiliation(s): Department of Dermatology, Gulhane School of Medicine, Ankara, Turkey.
msttnc@hotmail.com
Publication date & source: 2010, Int J Dermatol. , 49(12):1440-4
Topical antibiotics are the mainstay of therapy in mild to moderate inflammatory
acne. Topical erythromycin is one of the most common prescribed topical
antibiotics. Nadifloxacin, another topical antibiotic for acne, was recently
introduced into the market in our country. In this study, we compared the
efficacies and safety of topical nadifloxacin 1% cream and erythromycin 4% gel in
acne. A total of 86 patients with mild to moderate facial acne were randomized
into two treatment groups. The efficacies of the drugs were assessed by lesion
counts. An acne severity index (ASI) was also calculated. In both groups, there
was a significant reduction in lesion counts and ASI scores beginning from the
first visit at week 4. This reduction continued throughout the 12-week study
period. Both treatments were well tolerated. We conclude that when topically
applied, both nadifloxacin 1% cream and erythromycin 4% gel are equally effective
and safe treatments for mild to moderate facial acne.
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