Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan.

Author(s): Tsuruoka S, Wakaumi M, Ioka T, Yamamoto H, Ando H, Sugimoto K, Fujimura A

Affiliation(s): Department of Pharmacology, Division of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan. tsuru@jichi.ac.jp

Publication date & source: 2005-08, Br J Clin Pharmacol., 60(2):204-7.

Publication type: Randomized Controlled Trial

AIMS: To compare the degree of taste disturbance by candesartan and valsartan. METHODS: Candesartan cilexetil (4 mg day(-1)), valsartan (40 mg day(-1)), or vehicle was given to subjects (n = 8) for 13 days in a randomized, placebo-controlled, three-way crossover design with a 14-days washout period. Gustometry by filter-paper test and electrogustometry were performed before and at the end of each trial. Plasma renin activity and zinc concentrations in serum and saliva were measured. RESULTS: Detection thresholds of four basic tastes (sweet, salty, sour and bitter) by paper-disc test and electrogustometry were significantly worsened and plasma renin activity was elevated after the test, while the effects of two drugs did not significantly differ. These drugs did not affect zinc concentrations. CONCLUSION: Both candesartan and valsartan similarly alter taste sensitivity after the repeated dosing of the drug.