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Three-year prospective randomized study of incidence of posterior capsule opacification in eyes treated with topical diclofenac and betamethasone.

Author(s): Tsuchiya T, Ayaki M, Onishi T, Kageyama T, Yaguchi S

Affiliation(s): Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, Yokohama, Japan.

Publication date & source: 2003-03, Ophthalmic Res., 35(2):67-70.

Publication type: Clinical Trial; Randomized Controlled Trial

PURPOSE: To investigate the incidence of posterior capsule opacification (PCO) in eyes treated with diclofenac sodium (DFNa) and betamethasone phosphate (BMS) ophthalmic solutions. METHODS: A total of 200 eyes with silicone intraocular lens implantation were treated with topical agents for 3 months postoperatively. Twenty-six cases of the DFNa group and 34 of the BMS group met the criteria, and the severity of PCO was evaluated after 3 years. RESULTS: The results of axial densitometry by Scheimpflug photography were 27.8 computer-compatible tapes (CCT) in the DFNa-treated group and 32.6 CCT in the BMS-treated group (p = 0.1539). Posterior capsulotomy was performed in 11.5% of the DFNa group and 17.6% of the BMS group (p = 0.8375). The photographic grading of PCO showed no difference. CONCLUSION: The incidence of PCO in eyes treated with DFNa appears to be equal to that after BMS treatment. Copyright 2003 S. Karger AG, Basel

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