Effects of ondansetron on portal hemodynamics in liver cirrhosis.
Author(s): Tripkovic M(1), Kozjek F, Krizman I, Jereb J, Francetic I, Grabnar I, Mrhar A.
Affiliation(s): Author information:
(1)Department of Gastroenterology, Clinical Centre of Ljubljana, Slovenia.
Publication date & source: 2000, Int J Clin Pharmacol Ther. , 38(9):436-40
OBJECTIVE: The double-blind randomized pilot study was undertaken to compare the
effects of a 10-day course of ondansetron 8 mg/day and propranolol 80 mg/day
perorally in treating portal hypertension. SUBIECTS AND METHODS: 16 patients with
liver disease were enrolled in the study. Measurements of portal vein diameter,
portal blood flow velocity and portal blood flow volume were done at days 1, 5
and 10 of treatment using duplex Doppler sonography.
RESULTS: The propranolol group demonstrated a decrease in portal venous diameter,
while patients treated with ondansetron exhibited reduced portal blood flow
velocity values. A decreased portal blood flow volume was found in both groups
after 10 days of therapy.
CONCLUSION: No statistically significant differences were found between the
groups with the exception of portal venous diameter which is significantly lower
at the end of the treatment in the case of propranolol.
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