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Evaluation of bioavailability upon oral administration of phytonadione preparations in beagle dogs.

Author(s): Tokumura T, Tsushima Y, Machida Y, Kayano M, Nagai T

Affiliation(s): Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.

Publication date & source: 1993-03, Biol Pharm Bull., 16(3):319-21.

Bioavailability of phytonadione was investigated after oral administration to beagle dogs. The administrations of phytonadione in a surfactant solution (preparation a) and in an oleic acid solution (preparations b) greatly increased the bioavailability of phytonadione. The AUCs of preparations a and b were about 2.5 times larger than those of commercially available tablets A and C. This result well corresponded to the results of the dissolution test previously reported. The absorption of phytonadione from the gastro-intestinal tract was affected by food and the bioavailability was largely increased under non-fasted conditions. However, a large scatter was observed in the data, and it was found that the evaluation of the bioavailability of phytonadione preparations could not be done in non-fasted animals.

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