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Early disease control by low-dose prednisone comedication may affect the quality of remission in patients with early rheumatoid arthritis.

Author(s): Todoerti M, Scire CA, Boffini N, Bugatti S, Montecucco C, Caporali R

Affiliation(s): Division of Rheumatology, University of Pavia, IRCCS S. Matteo Foundation, Piazzale Golgi, Pavia, Italy.

Publication date & source: 2010-04, Ann N Y Acad Sci., 1193(1):139-45.

Publication type: Randomized Controlled Trial

In order to identify rate and stability of remission induced by low-dose prednisone comedication in early rheumatoid arthritis (RA), we evaluated patients with early RA (<1 year) who were randomized to receive (P) or not (non-P) low-dose prednisone in association with step-up disease-modifying antirheumatic drug therapy over 2 years. Prevalence and duration of clinical remission were evaluated in the first and second year. Each treatment group included 105 patients; no significant differences were found at baseline. During the first year, P patients achieved higher rates of clinical remission with a time-averaged odds ratio (OR) of 1.965 (CI 95% 1.214-3.182, P= 0.006). Moreover, they showed a higher probability of sustained remission during the second year (OR 4.480, CI 95% 1.354-14.817, P= 0.014). In conclusion, we found as in early RA low-dose prednisone comedication is associated with higher rate of clinical remission, earlier disease activity control and more stable remission over time.

Page last updated: 2010-10-05

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