Single dose fosfomycin trometamol versus multiple dose nitrofurantoin in pregnant women with bacteriuria: preliminary results.

Author(s): Thoumsin H, Aghayan M, Lambotte R

Affiliation(s): Department of Gynecology and Obstetrics, University Hospital, Liege, Belgium.

Publication date & source: 1990, Infection., 18 Suppl 2:S94-7.

Publication type: Clinical Trial; Randomized Controlled Trial; Review

Pregnancy induces anatomical and physiological changes in the urinary tract. In this condition a bacteriuria, even asymptomatic, may lead more frequently to pyelonephritis. Asymptomatic bacteriuria in pregnant women has therefore got to be treated. According to recent studies, long course antibiotherapy did not prove to be more effective than a single-dose one in the case of non-complicated bacteriuria. Moreover, the maternal and foetal toxicity should be reduced in the latter regimen. In this paper we present the preliminary results of our study comparing a single-dose treatment by fosfomycin trometamol (3 g) and nitrofurantoin (200 mg per day during a week).