Effect of meloxicam on postoperative pain after abdominal hysterectomy.

Author(s): Thompson JP, Sharpe P, Kiani S, Owen-Smith O

Affiliation(s): University Department of Anaesthesia, Leicester Royal Infirmary, UK.

Publication date & source: 2000-02, Br J Anaesth., 84(2):151-4.

Publication type: Clinical Trial; Randomized Controlled Trial

We studied 36 patients, allocated randomly to receive meloxicam 15 mg rectally (n = 18) or placebo suppository (n = 18) before total abdominal hysterectomy in a double-blind study. Visual analogue scores for pain at rest (P < 0.005), on movement (P < 0.05) and on coughing (P < 0.05) were significantly decreased in the meloxicam group during the first 24 h after surgery. Mean 24-h PCA morphine requirements were 33.2 (SD 16.9) mg and 38.2 (20.8) mg in the meloxicam and placebo groups, respectively (ns). There was no difference in the incidence of nausea, vomiting or sedation between groups.