Placental and fetal toxicity of albendazole sulphoxide in Wistar rats.

Author(s): Teruel MT, Felipe AE, Solana HD, Sallovitz JM, Lanusse CE

Affiliation(s): Lab. de Embriologia, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.

Publication date & source: 2003-06, Vet Hum Toxicol., 45(3):131-6.

Publication type: Clinical Trial; Randomized Controlled Trial

This work characterized the effects of albendazole sulphoxide (ABZSO) on placental and fetal parameters in Wistar rats on day 20 of gestation. ABZSO was fed in laboratory chow at 0, 2.5, 5, 10, 20 or 30 mg/kg/d from day 6 to 15 of gestation to pregnant rats. Data of resorptions, placental and fetal characteristics and fetal skeletal malformations were recorded. Resorption percentages in the 20 and 30 mg/kg/d groups were significantly higher compared to the control group. Placentas of ABZSO-treated rats had lower weight and smaller size than untreated rats. The fetal weight and size were lower in the 5 mg/kg/d dose compared to no treatment. In the 5, 10 and 20 mg/kg/d groups, reductions in ossification process were observed. ABZSO induced malformations and/or fetal death when orally administered to pregnant rats. This data contributes to characterization of the reproductive toxicity of ABZSO, the main active metabolite of albendazole.