Methsuximide for intractable childhood seizures.

Author(s): Tennison MB, Greenwood RS, Miles MV

Affiliation(s): Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill 27599-7025.

Publication date & source: 1991-02, Pediatrics., 87(2):186-9.

Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency. No serious or irreversible adverse effects were seen. Methsuximide is frequently overlooked and may be an effective adjunctive antiepileptic for children with intractable seizures.