Tranexamic Acid Reduces Blood Loss in Off-Pump Coronary Artery Bypass Surgery.

Author(s): Taghaddomi RJ, Mirzaee A, Attar AS, Shirdel A

Affiliation(s): Departments of ()Anesthesiology and double daggerHematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran.

Publication date & source: 2008-12-20, J Cardiothorac Vasc Anesth., [Epub ahead of print]

OBJECTIVE: This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery. DESIGN: A prospective, randomized, double-blind, placebo-controlled study. SETTING: The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University. PARTICIPANTS: One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups. INTERVENTIONS: Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline. MEASUREMENT AND MAIN RESULTS: Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units). CONCLUSION: Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products.