Influence of surfactants of Rofam type on properties of piroxicam tablets.

Author(s): Szulc-Musiol B, Jankowski A

Affiliation(s): Department of Applied Pharmacy and Drug Technology, Faculty of Pharmacy, Medical University of Silesia, 3 Kasztanowa, St., 41-200 Sosnowiec, Poland. bszulc@sum.edu.pl

Publication date & source: 2009-03, Acta Pol Pharm., 66(2):195-200.

Publication type:

Possibilities of application of non-ionic surfactants of Rofam type as solubilizers for piroxicam poorly dissolved in water were assessed. Homologous series of Rofams containing oxyethylene segments from 3 to 18 were used in the study. Tablet formulation was made by wet granulation technique using these surfactants in order to improve drug dissolution properties. Influence of both quantity and type of Rofam on morphological parameters of granules and tablets was investigated. All the examined parameters met the pharmacopeal norms. Paddle method was used to evaluate piroxicam pharmaceutical availability. The presence of non-ionic surfactants in composition of tablet mass improved dissolution rate of piroxicam.