Olive (Olea europaea) leaf extract effective in patients with stage-1
hypertension: comparison with Captopril.
Author(s): Susalit E, Agus N, Effendi I, Tjandrawinata RR, Nofiarny D, Perrinjaquet-Moccetti
T, Verbruggen M.
Affiliation(s): Nephrology & Hypertension Division, Department of Internal Medicine, Faculty of
Medicine, University of Indonesia/Dr. Cipto Mangunkusumo National General
Hospital, Jl. Diponegoro 71, Jakarta 10430, Indonesia.
Publication date & source: 2011, Phytomedicine. , 18(4):251-8
A double-blind, randomized, parallel and active-controlled clinical study was
conducted to evaluate the anti-hypertensive effect as well as the tolerability of
Olive leaf extract in comparison with Captopril in patients with stage-1
hypertension. Additionally, this study also investigated the hypolipidemic
effects of Olive leaf extract in such patients. It consisted of a run-in period
of 4 weeks continued subsequently by an 8-week treatment period. Olive (Olea
europaea L.) leaf extract (EFLA(®)943) was given orally at the dose of 500 mg
twice daily in a flat-dose manner throughout the 8 weeks. Captopril was given at
the dosage regimen of 12.5 mg twice daily at start. After 2 weeks, if necessary,
the dose of Captopril would be titrated to 25 mg twice daily, based on subject's
response to treatment. The primary efficacy endpoint was reduction in systolic
blood pressure (SBP) from baseline to week-8 of treatment. The secondary efficacy
endpoints were SBP as well as diastolic blood pressure (DBP) changes at every
time-point evaluation and lipid profile improvement. Evaluation of BP was
performed every week for 8 weeks of treatment; while of lipid profile at a 4-week
interval. Mean SBP at baseline was 149.3±5.58 mmHg in Olive group and 148.4±5.56
mmHg in Captopril group; and mean DBPs were 93.9±4.51 and 93.8±4.88 mmHg,
respectively. After 8 weeks of treatment, both groups experienced a significant
reduction of SBP as well as DBP from baseline; while such reductions were not
significantly different between groups. Means of SBP reduction from baseline to
the end of study were -11.5±8.5 and -13.7±7.6 mmHg in Olive and Captopril groups,
respectively; and those of DBP were -4.8±5.5 and -6.4±5.2 mmHg, respectively. A
significant reduction of triglyceride level was observed in Olive group, but not
in Captopril group. In conclusion, Olive (Olea europaea) leaf extract, at the
dosage regimen of 500 mg twice daily, was similarly effective in lowering
systolic and diastolic blood pressures in subjects with stage-1 hypertension as
Captopril, given at its effective dose of 12.5-25 mg twice daily.
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