Effect of restraint stress duration on humoral immune response in albino rats: modulation by chlordiazepoxide.

Author(s): Suresh PS, Doureradjou P, Nandakumar DN, Koner BC

Affiliation(s): Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Publication date & source: 2008, Immunopharmacol Immunotoxicol., 30(4):701-9.

Publication type: Comparative Study

We evaluated the effect of restraint stress (1 hr/day) for 6, 10, 14 and 21 days on antibody response against sheep RBC (SRBC) and modulation by chlordiazepoxide (CDP) pretreatment (10 mg/kg/day) in albino rats. Anti-SRBC titer was significantly decreased with increase in number of days of restraint stress exposure. CDP pretreatment significantly reversed the effects of 6, 10 and 14 (but not of 21) days of restraint stress. CDP treatment for 21 days per se suppressed immune response, but no additive effect was observed. CDP was not effective in chronic stress (i.e., 21 days of stress). Hence, the rationale behind benzodiazepines therapy in chronic stress needs to be evaluated.