The effects of preemptive pregabalin on attenuation of stress response to
endotracheal intubation and opioid-sparing effect in patients undergoing off-pump
coronary artery bypass grafting.
Author(s): Sundar AS, Kodali R, Sulaiman S, Ravullapalli H, Karthekeyan R, Vakamudi M.
Affiliation(s): Department of Cardiac Anaesthesiology, Sri Ramachandra Medical College and
Research Institute, Porur, Chennai, India.
Publication date & source: 2012, Ann Card Anaesth. , 15(1):18-25
The clinical study was designed to evaluate and compare single preoperative dose
of pregabalin to a placebo regarding hemodynamic responses to laryngoscopy and
endotracheal intubation, to assess perioperative fentanyl requirement and any
side-effects. It was a randomized, double-blind, placebo-controlled, parallel
assignment, efficacy study. The study was done at a tertiary university hospital.
This study was a comparison between two groups of 30 adult patients scheduled for
elective off pump coronary artery bypass surgery. In the control group, the
patients were given placebo capsules, and in the pregabalin group, the patients
were given pregabalin 150 mg capsule orally 1 h before surgery. The patients were
compared for hemodynamic changes before the start of the surgery, after
induction, 1, 3, and 5 min after intubation. Additionally, fentanyl requirement
during surgery and the first postoperative day was also compared. The present
study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery
attenuated the pressor response to tracheal intubation in adults, but the drug
did not show any effect on perioperative opioid consumption and was devoid of
side-effects in the given dose.