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Comparison of add-on valproate and primidone in carbamazepine-unresponsive patients with partial epilepsy.

Author(s): Sun MZ, Deckers CL, Liu YX, Wang W

Affiliation(s): Department of Neurology, The First Hospital of Shanxi Medical University, Taiyuan, China. meizhensun23@yahoo.com

Publication date & source: 2009-03, Seizure., 18(2):90-3. Epub 2008 Jul 30.

Publication type: Comparative Study; Randomized Controlled Trial

PURPOSE: Evaluation of the efficacy of add-on valproate (VPA) or primidone (PRM) in patients with partial epilepsy unresponsive to carbamazepine (CBZ). METHODS: The trial was prospective and open. Patients, aged 8-58 years, with partial epilepsy who did not become seizure free on CBZ were randomized to either VPA add-on or PRM add-on. The baseline period and the evaluation period were both 3 months. Proportions of patients with different degrees of reduction in seizure frequency were determined. RESULTS: Significantly more patients on VPA (51% of 68 patients) achieved a greater than 50% seizure reduction than on PRM (34% of 68 patients). There was no significant difference in percentage seizure free (26% and 16%, respectively) or in percentage treatment withdrawals due to adverse effects. CONCLUSION: Our results indicated that the efficacy of the CBZ/VPA combination tends to be greater than the efficacy of the CBZ/PRM combination.

Page last updated: 2009-10-20

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