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[The levels of HBsAg can predict the efficacy of peglated interferon-alpha 2a combined with adefovir dipivoxil, in HBeAg-positive chronic hepatitis B patients].

Author(s): Sun HX, Cao H, Zhang K, Yang XA, Li G, Xu QH

Affiliation(s): Department of Infectious Disease, Third Affiliated Hospital of Sun-Yat-Sen University, Guangzhou 510630, China.

Publication date & source: 2011-04, Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi., 25(2):132-4.

Publication type: Clinical Trial; English Abstract; Research Support, Non-U.S. Gov't

OBJECTIVE: To investigate the levels of HBsAg in predicting the efficacy of peglated interferon-alpha 2a combined with adefovir dipivoxil (ADV), in HBeAg-positive chronic hepatitis B patients. METHODS: This trial enrolled 62 HBeAg-positive chronic hepatitis B patients with detectable HBsAg for at least 6 months prior to screening, serum HBV DNA levels of at least 100 000 IU/ml. The efficacy assessment: viral suppression below 100 IU/ml. The patients with HBV DNA < or = 100 IU/ml after 24 weeks therapy were divided into group A, in which monotherapy continued; While the rest were divided into group B, in which ADV was combined until week 48. In group B, at the end-of-treatment, the patients with HBV DNA < or = 100 IU/ml were divided into group B1, the rest were divided into group B2. RESULTS: There was no significant difference on the baseline characteristics of patients between B1 and B2. There was significant difference on the levels of HBsAg at 12-week and 24-week between B1 and B2; while there was no significant difference on the levels of HBeAg. CONCLUSIONS: The levels of HBsAg at 12-week and 24-week would be predictors to evaluate the efficacy of combined therapy in HBeAg-positive chronic hepatitis B patients.

Page last updated: 2011-12-09

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