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Tobacco dependence treatment for hospitalized smokers: a randomized, controlled, pilot trial using varenicline.

Author(s): Steinberg MB, Randall J, Greenhaus S, Schmelzer AC, Richardson DL, Carson JL

Affiliation(s): Division of General Internal Medicine, University of Medicine and Dentistry of New Jersey--Robert Wood Johnson Medical School, 125 Paterson Street, Suite 2304, New Brunswick, NJ 08903, USA. michael.steinberg@umdnj.edu

Publication date & source: 2011-12, Addict Behav., 36(12):1127-32. Epub 2011 Jul 23.

Publication type: Research Support, Non-U.S. Gov't

OBJECTIVE: The hospital can be an important opportunity for smoking cessation interventions. This is the first randomized, double-blinded, placebo-controlled pilot trial utilizing varenicline and post-discharge, in-person behavioral treatment for hospitalized smokers. METHOD: Seventy-nine smokers admitted to a university-based hospital with various diagnoses were enrolled from 2007 to 2009. The primary outcome was biochemically confirmed abstinence at 24 weeks following discharge. Secondary outcomes included withdrawal symptoms, motivation, utilization of treatment, and medical events. RESULTS: Overall abstinence at 24 weeks was 27% with no difference between varenicline and placebo treatment groups (23% vs. 31%). There were no significant differences in motivation to stop smoking or withdrawal symptoms. Over 40% of all subjects utilized post-discharge behavioral treatment with significantly higher abstinence rates compared with those who did not (53.1% vs. 8.5%, p<0.01). Overall adverse events were similar in both treatment groups with the only significant difference being more nausea in the varenicline group (25% vs. 5%; p<0.01). Twenty-three subjects were re-hospitalized with no significant differences between treatment groups (13 varenicline vs. 10 placebo). CONCLUSION: This pilot trial of varenicline in hospitalized smokers demonstrated feasibility of implementation, produced some hypothesis-generating findings, and suggested the potential benefit of face-to-face treatment following discharge. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Page last updated: 2011-12-09

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