Effects of reboxetine and citalopram on appraisal of infant facial expressions
and attentional biases.
Author(s): Stein A, Murphy S, Arteche A, Lehtonen A, Harvey A, Craske MG, Harmer C.
Affiliation(s): Department of Psychiatry, University of Oxford, Oxford, UK.
alan.stein@psych.ox.ac.uk
Publication date & source: 2012, J Psychopharmacol. , 26(5):670-6
Difficulties in mother-child interaction are commonly observed in the context of
postnatal depression. These difficulties may result in part from the negative
cognitive bias present in depression, which may in turn lead to biased negative
perceptions of the infant: in particular, these biases encompass the negative
appraisal of facial expressions. Given the important role of early mother-child
interactions in child development it is vital to investigate potential
interventions that might be beneficial in ameliorating the negative cognitive
bias. This study aimed to examine the effects of two different antidepressants
(reboxetine and citalopram) on the appraisal of infant facial expressions of
emotion using a faces rating task, and on attention to infant emotion using an
attentional probe. Thirty-nine volunteers were randomly assigned to a
double-blind 7-day intervention with either placebo, citalopram or reboxetine.
There were significant positive effects on the appraisal of facial expressions;
participants assigned to the placebo group rated positive faces less positively
than those either in the citalopram or in the reboxetine groups. However, there
was no evidence that these drugs had an effect on attentional vigilance. If
antidepressants are able to help a mother to perceive her infant's facial
expressions as more positive, this may lead to more positive interactions,
thereby potentially mitigating the negative effects of depression on infant
development. These findings should be treated with caution until replicated in
larger and clinical samples.
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