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Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial.

Author(s): Stanislavov R, Nikolova V, Rohdewald P

Affiliation(s): 1Department of Obstetrics and Gynecology, Medical University Sofia, Faculty of Medicine, Sofia, Bulgaria.

Publication date & source: 2007-08-16, Int J Impot Res., [Epub ahead of print]

In a randomly allocated, double-blind, placebo-controlled, crossover design, 50 patients with mild to moderate erectile dysfunction (ED) were treated for 1 month with placebo or a combination of L-arginine aspartate and Pycnogenol (Prelox). Patients reported sexual function from diaries. Testosterone levels and endothelial NO synthase (e-NOS) were monitored along with routine clinical chemistry. Intake of Pycnogenol for 1 month restored erectile function to normal. Intercourse frequency doubled. e-NOS in spermatozoa and testosterone levels in blood increased significantly. Cholesterol levels and blood pressure were lowered. No unwanted effects were reported. Prelox is a promising alternative to treat mild to moderate ED.International Journal of Impotence Research advance online publication, 16 August 2007; doi:10.1038/sj.ijir.3901597.

Page last updated: 2007-10-18

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