Additional reduction in blood pressure after cholesterol-lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin-converting enzyme inhibitors (enalapril or lisinopril).

Author(s): Sposito AC, Mansur AP, Coelho OR, Nicolau JC, Ramires JA

Affiliation(s): Heart Institute (InCor), University of Sao Paulo Medical School, SP, Brazil.

Publication date & source: 1999-05-15, Am J Cardiol., 83(10):1497-9, A8.

Publication type: Clinical Trial; Randomized Controlled Trial

Blood pressure (BP) reduction was compared between patients receiving angiotensin-converting enzyme inhibitors alone and patients receiving these medications plus statins after 3 months of dietary intervention. Although BP was similarly reduced at week 4, the statin-treated group had a greater reduction in BP and total cholesterol levels at week 16, suggesting a synergistic effect between cholesterol lowering with statins and angiotensin-converting enzyme inhibitor treatment for hypertensive patients.