Ramipril reduces QT dispersion in patients with acute myocardial infarction and heart failure.

Author(s): Spargias KS, Lindsay SJ, Hall AS, Cowan JC, Ball SG

Affiliation(s): Institute for Cardiovascular Research, University of Leeds, United Kingdom.

Publication date & source: 1999-03-15, Am J Cardiol., 83(6):969-71, A10.

Publication type: Clinical Trial; Randomized Controlled Trial

In a cohort of 67 patients from the Acute Infarction Ramipril Efficacy study, we showed that ramipril therapy was associated with a significant reduction in QT dispersion over a 2-month period after acute myocardial infarction. This reduction of ventricular repolarization inhomogeneity indicates an antiarrhythmic effect and may be an important additional mechanism for the reduced all-cause mortality and sudden death incidence achieved with angiotensin-converting enzyme inhibition after acute myocardial infarction.