[Assessment of vertebral fractures on radiographs and the effects of drug therapy
on vertebral fractures]. [Article in Japanese]
Author(s): Soen S.
Affiliation(s): Department of Orthopaedic Surgery and Rheumatology, Nara Hospital, Kinki
University School of Medicine.
Publication date & source: 2011, Clin Calcium. , 21(7):963-9
Vertebral radiographs remain the best method for assessing the presence of
vertebral fractures. Both quantitative morphometric (QM) and semiquantitative
morphometric (SQ) techniques are using for the assessment of prevalent as well as
incident vertebral fractures on radiographs. Recently, SQ method has been mainly
used for clinical study. A prevalent fracture is defined as a vertebral body with
a SQ grade of 1 or more, and an incident fracture is defined as an increase of at
least 1 grade in a vertebral body. Randomized placebo-controlled double- blind
studies indicated that usable drugs in Japan, for example, oral amino-
bisphophonates, SERMs, and teriparatide significantly reduced the risk of
vertebral fracture, and relative risk reduction were 30 to 65%.
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