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Postoperative lomefloxacin 0.3% prophylaxis in strabismus surgery.

Author(s): Snir M, Hasanreisoglu M, Friling R, Goldenberg-Cohen N, Ehrlich R, Bagan J, Axer-Siegel R

Affiliation(s): Pediatric Ophthalmology Unit, Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel. msnir@clalit.org.il

Publication date & source: 2008-10, Curr Eye Res., 33(10):819-25.

PURPOSE: To evaluate the efficacy of topical lomefloxacin 0.3% versus chloramphenicol 0.2% with polymyxin B 2500 U/ml in the treatment of patients after strabismus surgery. METHODS: Seventy-nine consecutive patients who underwent strabismus surgery from April through October 2006 were randomized to receive topical lomefloxacin 0.3% (n = 45, 58 eyes) or chloramphenicol 0.2% with polymyxin B 2500 U/ml (n = 34, 40 eyes) postoperatively, in addition to topical dexamethasone 0.1% and diclophenac 0.1%. The groups were compared for clinical signs of local cellulitis and findings on conjunctival cultures. RESULTS: From postoperative day 1 to day 28, rates of chemosis decreased from 96% to 9.5% in the lomefloxacin group and from 94% to zero in the chloramphenicol group; rates of hyperemia decreased from 100% to zero in both groups. Accordingly, rates of a cumulative clinical sign score (CCSS) decreased from 60% to zero in the lomefloxacin group and 50% to zero in the chloramphenicol group. Rates of positive bacterial cultures dropped from 59.6% preoperatively to 48.3% on day 14 in the lomefloxacin group and from 63% to 47% in the chloramphenicol group. CONCLUSIONS: Topical lomefloxacin is a potent alternative to topical chloramphenicol eye drops after strabismus surgery for the control of pain, infection and discharge, chemosis, hyperemia, and conjunctival hemorrhage.

Page last updated: 2008-11-03

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