[Treatment of mycotic skin infections]

Author(s): Simaljakova M

Affiliation(s): Dermatovenerologicka klinika Lekarskej fakulty Univerzity Komenskehov Bratislave, Slovakia.

Publication date & source: 1995-03, Bratisl Lek Listy., 96(3):141-3.

Publication type: Clinical Trial

Mycotic infections of the skin remain still to represent a therapeutic problem. The development of new antimycotics widens the possibilities of therapy. One of them is oxiconasolnitrate which is a derivate of of imadazole. It is available on our market as Myfungar cream. The clinical postregistration study verified the effectivity of this preperation. The examined group was constituted of 30 patients. 24 patients were afflicted with epidermophytia inguinalis, 1 patient with epidermophytia cruris, 1 patient with epidermophytia manuum, 1 patient with trichophytia corporis and 2 with candidosis submammaris. Cultivation examination revealed 20 time Trichophyton rubrum, one time Trichophyton mentagrophytes var. interdigitale, one time Trichophyton mentagrophytes var. granulosum, one time Epidermophyton floccosum, and 2 time Candida albicans. Therapy lasted 21-42 days. All patients were treated for a period of 6 weeks. 24 treated cases after the therapy included 10 wit persistent squamming, 4 cases with erythema, 3 cases with infiltration, and 1 case with persistent vesiculation. 4 patients suffered from itch irritation, and 1 from pain. 4 patients were not evaluated for their therapy was interrupted. Cultivation examinations in 5 cases revealed the presence of T. rubrum. Microscopic examinations were positive in 10 patients. Following 6 weeks of therapy 20% of patients remained to yield positive cultivation findings and 40% of patients were microscopically positive. 2 patients with candidosis were clinically cured and their laboratory findings were negative in 5-6 weeks. Myfungar creme is a preparation which had in 80% of patients a ver y good or good therapeutic effect. Its low sensibilization abilities and application once per day are advantageous. (tab. 6, Ref. 6.)