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Natural medicaments in endodontics -- a comparative study of the anti-inflammatory action.

Author(s): Silva FB, Almeida JM, Sousa SM

Affiliation(s): Center of Biological Sciences and Professions of Health, University of Sacred Heart, Bauru.

Publication date & source: 2004-04, Pesqui Odontol Bras., 18(2):174-9. Epub 2004 Aug 5.

Publication type: Clinical Trial

The objective of this study was to evaluate the irritant potential of propolis, Casearia sylvestris, Otosporin and saline solution (control). Twenty-eight male Wistar rats were selected, anesthetized and four experimental sites were designed on their backs. Injections of 2% Evans blue were intravenously administered in the lateral caudal vein and 0.1 ml of the tested solutions was injected intradermally into the experimental sites. The animals were killed 1/2, 1, 3 and 6 hours after the injection of the solutions. Each piece of skin containing the lesion was immersed in formamide and incubated at 45 masculine C for 72 h. After filtration, optical density was measured in a spectrophotometer. Data were statistically analyzed by a 2-way non-parametric test. The highest values of extracted dye were observed at 3 hours characterizing a peak in the inflammatory process. Propolis was the least irritant solution. The natural medicaments tested in this study may be a valuable alternative for endodontic treatment.

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