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Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir.

Author(s): Siccardi M, D'Avolio A, Baietto L, Gibbons S, Sciandra M, Colucci D, Bonora S, Khoo S, Back DJ, Di Perri G, Owen A

Affiliation(s): Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.

Publication date & source: 2008-11-01, Clin Infect Dis., 47(9):1222-5.

Publication type: Research Support, Non-U.S. Gov't

This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.

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