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Effects of desogestrel on carbohydrate metabolism.

Author(s): Shoupe D

Affiliation(s): Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles 90033.

Publication date & source: 1993-03, Am J Obstet Gynecol., 168(3 Pt 2):1041-7.

Publication type: Review

Associated with progesterone and the synthetic progestins used in oral contraceptives is a dose-dependent impairment of carbohydrate metabolism. It is well known that in the general population hyperinsulinemia and alterations in glucose metabolism are significant risk factors for the development of cardiovascular disease. Studies that use curve analysis of glucose tolerance tests have demonstrated insulin resistance, rises in plasma insulin, and relative glucose intolerance in women using oral contraceptives. Desogestrel, a new progestin, has been demonstrated to have generally less pronounced effects on these parameters of carbohydrate metabolism.

Page last updated: 2006-01-31

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