Comparison of the effects of Matricaria chamomila (Chamomile) extract and
mefenamic acid on the intensity of premenstrual syndrome.
Author(s): Sharifi F(1), Simbar M(2), Mojab F(3), Majd HA(4).
Affiliation(s): Author information:
(1)International Branch, Shahid Beheshti University of Medical Sciences, Tehran,
Iran. Electronic address: f_sharifi44@yahoo.com.
(2)Department of Midwifery and Reproductive Health, Shahid Beheshti University of
Medical Sciences, Tehran, Iran. Electronic address: msimbar@sbmu.ac.ir.
(3)Department of Pharmacognosy, Shahid Beheshti University of Medical Sciences,
Tehran, Iran. Electronic address: sfmojab@yahoo.com.
(4)Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran,
Iran. Electronic address: alavimajd@gmail.com.
Publication date & source: 2014, Complement Ther Clin Pract. , 20(1):81-8
The study aimed to compare the effects of Chamomile Extract and Mefenamic acid
(MA) on the intensity of Premenstrual syndrome (PMS) symptoms. This study was a
clinical randomized double blind trial, carried out with 90 students living in
the dorms of Iran. The participants filled the daily forms about the intensity of
PMS for two consecutive months. Once the definitive diagnosis of PMS was made,
the participants were divided into two groups, each receiving either Chamomile
capsule 100 mg or MA 250 mg three times a day. Intensity reduction of emotional
symptoms was significantly higher among Chamomile Extract-users (30.1 ± 26.6 and
33.4 ± 25.3 percent) than that among MA-users (11.6 ± 25.7 and 10.7 ± 26.8
percent) after two cycles intervention (p < 0.001). Intensity reduction of
physical symptoms was not significantly different (p > 0.05) among groups.
Consumption of Chamomile seems to be more effective than MA in relieving the
intensity of PMS associated symptomatic psychological pains.
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