Disadvantages of VKA and requirements for novel anticoagulants.
Author(s): Shameem R(1), Ansell J.
Affiliation(s): Author information:
(1)Department of Internal Medicine, Lenox Hill Hospital, New York, NY 10075, USA.
rshameem@nshs.edu
Publication date & source: 2013, Best Pract Res Clin Haematol. , 26(2):103-14
Vitamin K antagonists have been in wide use for over 70 years. Warfarin, the most
commonly used vitamin K antagonist, has been shown to be highly effective in
treating and preventing thrombosis. Despite this, warfarin has many
disadvantages, which has led to the development of a new class of oral
anticoagulants targeted to specific coagulation factors designated as
target-specific oral anticoagulants (TSOAs). TSOAs include the thrombin
inhibitors (dabigatran) and factor Xa inhibitors (rivaroxaban, apixaban). This
chapter reviews the disadvantages of warfarin and evaluates both the advantages
and disadvantages of the new oral anticoagulants.
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