Peroperative adenosine infusion reduces isoflurane concentrations during general
anesthesia for shoulder surgery.
Author(s): Segerdahl M, Persson E, Ekblom A, Sollevi A.
Affiliation(s): Department of Anesthesia and Intensive Care, Karolinska Hospital, Stockholm,
Sweden.
Publication date & source: 1996, Acta Anaesthesiol Scand. , 40(7):792-7
BACKGROUND: Adenosine (ADO), and stable analogs thereof, have been shown to exert
antinociceptive action under experimental conditions in animals and in humans.
The aim of this randomized double-blind placebo-controlled study was to evaluate
if a low dose of intravenous (i.v.) ADO could reduce isoflurane requirements
during joint-associated surgery, as an indication of antinociception in deep
somatic pain.
METHODS: Thirty-two patients, age 19-62 years, ASA I and II, scheduled for
shoulder joint surgery, were assigned to receive an i.v. infusion of either
adenosine, 80 micrograms.kg-1.min-1, or placebo, during the surgical procedure.
Anesthesia was maintained with isoflurane/N2O/O2 inhalation.
RESULTS: The peroperative isoflurane concentration was significantly reduced at
50 minutes of surgery in the group receiving adenosine infusion. Also, the
systolic blood pressure level was peroperatively more stable during adenosine
infusion than during placebo. Other clinical parameters, such as pain,
postoperative analgesic requirements and nausea, were not different between
groups.
CONCLUSION: A peroperative infusion of a low dose of adenosine during shoulder
joint surgery may reduce the peroperative isoflurane requirement.
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