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Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? A Randomized Controlled Trial.

Author(s): Schuh S, Willan AR, Stephens D, Dick PT, Coates A

Affiliation(s): Divisions of Pediatric Emergency Medicine (S.S.), Pediatric Medicine (P.D.), Respirology (A.C.), Department of Pediatrics and Research Institute (A.W., D.S.), The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Publication date & source: 2009-08-03, J Pediatr., [Epub ahead of print]

OBJECTIVE: To examine whether outpatient post-stabilization therapy with montelukast produces more treatment failures than prednisolone. STUDY DESIGN: In this randomized, double-blind, double-dummy non-inferiority trial, 130 children 2 to 17 years of age with mild to moderate acute asthma stabilized with prednisolone in the emergency department received 5 daily treatments with either prednisolone or montelukast after discharge. The primary outcome was treatment failure within 8 days (ie, an asthma-related unscheduled visit, hospitalization, or additional systemic corticosteroids). RESULTS: The rates of treatment failure were 7.9% in the prednisolone group and 22.4% in the montelukast group (95% CI, 26.5%-2.4%). Treatment was more likely to fail in younger patients (odds ratio, 4.9). In the montelukast group, more patients received additional pharmacotherapy than in patients receiving prednisolone (23.9% versus 9.5%, P = .03). The differences in the daily salbutamol treatments, asymptomatic days, and changes in the Pediatric Respiratory Assessment Measure score were not significant (P = .85, .75, and .26, respectively). CONCLUSION: Montelukast does not represent an adequate alternative to corticosteroids after outpatient stabilization in mild to moderate acute asthma. This population should receive oral corticosteroids after discharge.

Page last updated: 2009-10-20

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