DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Effect of simulated microgravity on the disposition and tissue penetration of ciprofloxacin in healthy volunteers.

Author(s): Schuck EL, Grant M, Derendorf H

Affiliation(s): Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.

Publication date & source: 2005-07, J Clin Pharmacol., 45(7):822-31.

Publication type: Clinical Trial; Randomized Controlled Trial

This study evaluated the effects of simulated microgravity (smuG) on the pharmacokinetics of ciprofloxacin. Six healthy volunteers participated in a crossover study to compare the pharmacokinetics of ciprofloxacin after a single 250-mg oral dose in normal gravity (1G) and smuG. Plasma and urine samples were collected, and in vivo microdialysis was employed to obtain the free interstitial concentrations in the thigh muscle. Tissue penetration (f) was determined as the ratio of the free tissue area under the concentration versus time curve (AUC(tiss,free))/AUC(plasma,free). Plasma and free interstitial ciprofloxacin concentrations were simultaneously fit to a 1-compartment body model after correction for protein binding and tissue penetration. Total and free plasma concentrations were very similar in smuG and 1G. Tissue penetration in smuG (f =0.61 +/- 0.36) was slightly lower than in 1G (f =0.92 +/- 0.63); however, the difference was not significant. The authors conclude that the disposition of ciprofloxacin was not affected by simulated microgravity.

Page last updated: 2006-01-31

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017