Bacterial vaginosis: treatment with clindamycin cream versus oral metronidazole.

Author(s): Schmitt C, Sobel JD, Meriwether C

Affiliation(s): Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan.

Publication date & source: 1992-06, Obstet Gynecol., 79(6):1020-3.

Publication type: Clinical Trial; Randomized Controlled Trial

In a randomized, double-blind study, 48 women with symptomatic bacterial vaginosis were assigned to receive either 5 g of 2% clindamycin vaginal cream daily or 500 mg metronidazole oral tablets twice a day for 7 days. After completion of therapy, there was no significant difference in cure rates (clindamycin 72% versus metronidazole 87%). One month later, 61% of the patients in each group were still cured. Adverse reactions were mild in both groups. We conclude that clindamycin cream is a safe, well tolerated, and effective alternative to oral metronidazole for treatment of bacterial vaginosis.