Long-term linezolid treatment in a young child with extensively drug-resistant tuberculosis.

Author(s): Schaaf HS, Willemse M, Donald PR

Affiliation(s): Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children's Hospital, Cape Town, South Africa. hss@sum.ac.za

Publication date & source: 2009-08, Pediatr Infect Dis J., 28(8):748-50.

Publication type: Case Reports

Treatment of extensively drug-resistant tuberculosis (XDR-TB) is a challenge. We describe a young child with pulmonary XDR-TB who did not respond to an aggressive multidrug-resistant TB treatment regimen, but was cured with linezolid in combination with other reserve antituberculous drugs. No serious adverse events were observed during 19 months of treatment for XDR-TB.