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Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group.

Author(s): Sayar H, Chan RJ, Orschell CM, Chan EM, Yu Z, Hood D, Plett A, Yang Z, Hui CL, Nabinger SC, Kohlbacher KJ, West ES, Walter A, Sampson C, Wu J, Cripe LD

Affiliation(s): Division of Hematology and Oncology, Department of Medicine, Indiana University Simon Cancer Center, Indianapolis, IN 46202, USA. ssayar@iupui.edu

Publication date & source: 2011-08, Leuk Res., 35(8):1108-10. Epub 2011 Mar 21.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Prolonged administration of methyl transferase inhibitors may increase response rates in myelodysplastic syndromes (MDS). Fourteen MDS patients with anemia and less than 10% marrow blasts received azacitidine 50 mg/m(2) thrice weekly for 2 weeks every 4 weeks; 7 also received weekly erythropoietin. The response rate of 43% did not improve the rates reported with other azacitidine administration schedules, so the study was closed. A decreased apoptosis of primitive erythroid progenitors and increased expression of BclX(L) was observed with treatment in responding patients compared to non-responders. Azacitidine may modulate BclX(L) and improve erythropoiesis through reduction of apoptosis in primitive erythroid progenitor population in MDS. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Page last updated: 2011-12-09

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