Effect of estradiol valerate on endometrium thickness during clomiphene
citrate-stimulated ovulation.
Author(s): Satirapod C(1), Wingprawat S, Jultanmas R, Rattanasiri S, Jirawatnotai S,
Choktanasiri W.
Affiliation(s): Author information:
(1)Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol
University, Bangkok, Thailand.
Publication date & source: 2014, J Obstet Gynaecol Res. , 40(1):96-101
AIM: The aim of this study was to examine the effects of estradiol valerate (EV)
on the thickness of clomiphene citrate (CC)-stimulated endometrium.
MATERIAL AND METHODS: Thirty-four normal ovulatory women were randomized
double-blindly into two groups to receive CC 100 mg/day on day 2-6 of the
treatment cycle, and either vitamin B (placebo) or EV 6 mg/day on day 10-14 of
the cycle. The endometrial thickness, endometrial pattern, numbers of mature
follicles, and maximal diameters of preovulatory follicles were evaluated by
transvaginal sonographic examination.
RESULTS: Thirty women completed both treatment cycles. Two other participants
dropped out during the treatment due to side-effects (headache). The average
endometrial thickness of the group treated with CC + placebo became slightly
thinner when compared to the thickness at the baseline (9.04 vs 9.52 mm; P =
0.24). The CC + placebo and the CC + EV resulted in similar endometrial pattern,
ovulation day, numbers of mature follicles, and sizes of the leading follicles
before ovulation. However, an addition of EV into the CC cycle significantly
increased the average endometrial thickness (10.7 mm vs 9.04 mm; P < 0.001).
CONCLUSIONS: We concluded that the addition of 6 mg/day EV following the CC
treatment can prevent the endometrial thinning without perturbing
folliculogenesis and ovulation.
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