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Randomized treatment of patients with typhoid and paratyphoid fevers using norfloxacin or chloramphenicol.

Author(s): Sarma PS, Durairaj P

Affiliation(s): Department of Medicine, Jawaharlal Nehru Hospital and Research Centre, Bhilainagar, Madhya Pradesh, India.

Publication date & source: 1991-09, Trans R Soc Trop Med Hyg., 85(5):670-1.

Publication type: Clinical Trial; Randomized Controlled Trial

Forty adult patients with Salmonella typhi and S. paratyphi infections were studied in a randomly assigned prospective study to receive norfloxacin (12 drug-sensitive and 8 drug-resistant cases) or chloramphenicol (20 cases). No complication occurred in either group and no side effect was noted in the norfloxacin-treated group. The results suggest that a 7 d course of twice daily norfloxacin promises to be an alternative to a 14 d course of chloramphenicol for treating chloramphenicol-sensitive and multidrug-resistant typhoid and paratyphoid fevers.

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