Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers.

Author(s): Sansone-Parsons A, Krishna G, Calzetta A, Wexler D, Kantesaria B, Rosenberg MA, Saltzman MA

Affiliation(s): Schering-Plough Research Institute, K-15-4-4455, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. angela.sansone@spcorp.com

Publication date & source: 2006-05, Antimicrob Agents Chemother., 50(5):1881-3.

Publication type: Comparative Study ; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.