Comparison of changes of body water measured by using bioelectrical impedance analysis between lercanidipine and amlodipine therapy in hypertensive outpatients.

Author(s): Sansanayudh N, Wongwiwatthananukit S, Veerayuthvilai S

Affiliation(s): Cardiology Unit, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand. dr_nakarin@hotmail.com

Publication date & source: 2010-11, J Med Assoc Thai., 93 Suppl 6:S84-92.

Publication type: Randomized Controlled Trial

OBJECTIVE: To compare changes of body water measured by using bioelectrical impedance analysis (BIA), between lercanidipine and amlodipine therapy. MATERIAL AND METHOD: This is a prospective randomized open-label study in hypertensive outpatients. Eighty patients were randomized into two groups; 1) amlodipine 5 mg/d and 2) lercanidipine 10 mg/d. Patients were assessed for changes in total body water (TBW), extracellular water (ECW) and intracellular water (ICW) at week 4 and 8 after treatment. RESULTS: At baseline body water in both groups were similar. After treatment, both groups did not have significant changes in body water from baseline. Seven patients in amlodipine group (17.5%) and none of lercanidipine group developed edema; p = 0.012. Among those seven patients, TBW, ECW and ICW all increased significantly from baseline. CONCLUSION: BIA did not detected changes of body water in most patients. However, in patients who developed edema, TBW, ECW and LCW significantly increased from baseline with the greatest changes seen in extracellular compartment.