Contraception in hereditary angioedema.

Author(s): Sanhueza PI

Affiliation(s): Obstetrics and Gynaecology Department, Health Sciences Faculty, School of Medicine, Andres Bello University, Santiago, Chile. pab.sanhueza@uandresbello.edu

Publication date & source: 2008-11, Fertil Steril., 90(5):2015.e21-2. Epub 2008 Mar 6.

Publication type: Case Reports

OBJECTIVE: To report a case of successful use of a transdermal contraceptive in a patient with hereditary angioedema. DESIGN: Case report. SETTING: University medical center. PATIENT(S): A patient who had used oral contraceptives contracted SC and submucosal tumefaction every 1 or 2 months. She was diagnosed with type I hereditary angioedema. It was determined that she was complement C4 deficient and C1-inhibitor quantitative deficient but functional C1-inhibitor normal. After she was diagnosed, the use of oral contraceptives was contraindicated. INTERVENTION(S): Oral contraceptives were suspended, and a hormonal transdermal contraceptive was started. MAIN OUTCOME MEASURE(S): The absence of symptoms after 26 months using a transdermal contraceptive. RESULT(S): After 26 months of using this treatment, the patient has not experienced any symptoms of the hereditary angioedema. CONCLUSION(S): The use of hormonal contraceptives transdermally can be an alternative in patients with hereditary angioedema.