Effect of enalapril on left ventricular diameters and exercise capacity in asymptomatic or mildly symptomatic patients with regurgitation secondary to mitral valve prolapse or rheumatic heart disease.

Author(s): Sampaio RO, Grinberg M, Leite JJ, Tarasoutchi F, Chalela WA, Izaki M, Spina GS, Rossi EG, Mady C

Affiliation(s): Department of Valvular Heart Disease, University of Sao Paulo Medical School, Sao Paulo, Brazil. val_roney@incor.usp.br

Publication date & source: 2005-07-01, Am J Cardiol., 96(1):117-21.

Publication type: Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

The effects of 12 months of therapy were evaluated in 47 mildly symptomatic patients with moderate to severe mitral valve regurgitation; 26 patients received enalapril and 21 received a placebo. Enalapril was associated with a significant reduction in left ventricular diameter and mitral regurgitation volume, with no evidence of change in systolic function indexes. However, enalapril did not hinder progressive aerobic impairment to effort.