Comparison of urinary and recombinant human chorionic gonadotropin during ovulation induction in intrauterine insemination cycles: a prospective randomized clinical trial.
Author(s): Sakhel K, Khedr M, Schwark S, Ashraf M, Fakih MH, Abuzeid M
Affiliation(s): Synergy Medical Education Alliance, Michigan State University, Saginaw, Michigan; IVF Michigan PC, Rochester Hills, Michigan.
Publication date & source: 2007-04-10, Fertil Steril., [Epub ahead of print]
OBJECTIVES: To compare the in vivo effectiveness of recombinant (r) hCG with urinary (u) hCG during controlled ovarian hyperstimulation and intrauterine insemination (COH-IUI) cycles. DESIGN: Prospective controlled clinical study. SETTING: Private IVF center. PATIENT(S): Two hundred eighty-four subjects undergoing COH-IUI cycles. INTERVENTIONS(S): Women were randomized into receiving r-hCG or u-hCG for final maturation and induction of ovulation. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate and outcome of pregnancy. RESULT(S): Background characteristics were similar in the two groups studied except for a slight difference in the mean duration of infertility (3.0 vs. 2.3). There was no significant difference in the number of follicles >/=16 mm, mean peak E(2), or mean 1-week P levels between the two groups. The clinical pregnancy rate was 27.1% in the recombinant group compared with 28.5% in the urinary group. The outcome of pregnancy was similar in both groups. CONCLUSION(S): Recombinant hCG was found to be as effective as u-hCG in achieving pregnancy during COH-IUI cycles. This is in agreement with earlier studies on the effectiveness of r-hCG in IVF cycles.