Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth.

Author(s): Said TK, Moraes RC, Sinha R, Medina D

Affiliation(s): Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. tsaid@bcm.tmc.edu

Publication date & source: 2001, Breast Cancer Res., 3(2):122-33. Epub 2000 Dec 22.

Publication type: Research Support, U.S. Gov't, P.H.S.

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.