Comparison of the efficacy of intralesional triamcinolone acetonide and
5-fluorouracil tattooing for the treatment of keloids.
Author(s): Sadeghinia A, Sadeghinia S.
Affiliation(s): Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
asadeghinia@tums.ac.ir
Publication date & source: 2012, Dermatol Surg. , 38(1):104-9
BACKGROUND: Hypertrophic scars and keloids may complicate wound healing secondary
to trauma or surgery. A variety of treatment regimens have been used for
treatment of keloids.
OBJECTIVE: To compare 5-fluorouracil (5-FU) tattooing and intralesional steroid
for treatment of keloids.
METHODS: In this 44-week, double-blind, clinical trial, 40 patients were
randomized into two study groups. Patients in group 1 were given intralesional
triamcinolone acetonide (TAC), and patients in group 2 were treated with 5-FU
tattooing; both groups received treatment every 4 weeks for 12 weeks. Lesions
were assessed for erythema, pruritus, height, surface, and induration at baseline
(initiation of treatment) and at weeks 4, 8, 12, 20, 28, 36, and 44. All patients
had complete blood count, liver function tests, and renal function tests before
treatment and at week 20.
RESULTS: All the patients completed the study. At the 44-week follow-up visits,
both groups showed improvement in all parameters, but improvement was more
significant in the 5-FU group (p < .05). No side effect was detected in either of
the groups.
CONCLUSION: 5-FU tattooing was more effective than intralesional TAC for the
treatment of keloids.
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